Niclosamide: regimen of use, mechanism of action, indications, contraindications

Release form

Tablets 0.25 g

Mechanism, spectrum of action

This medicine is an anthelmintic.

• It disrupts oxidative phosphorylation,
• acts on two layers of cestode tegument,
• causes paralysis of neuromuscular tissue,
• reduces resistance to proteolytic enzymes,
• reduces the viability of eggs.

Contraindications are hypersensitivity to the drug and pregnancy.

Application diagram

The drug is taken orally in the form of a fine powder. Before each dose, you need to take 2 g of baking soda.

Hymenolipedosis

Adults are recommended to take 2-3 g per day orally. The daily dose is taken in 4 doses every 2 hours (at 10, 12, 14 and 16 hours), food is taken at 8, 13 and 18 hours. Treatment is carried out for 4 days, after 4 days it is repeated.

• Children under 2 years of age are prescribed 0.5 g per day,
• children 3-6 years old – 1 g per day,
• children 6-12 years old – 1.5 g per day,
• children over 12 years old – 2 g per day

within 3 days. In case of relapse, it is necessary to repeat the course according to the same scheme.

Taeniasis , teniarynchosis , diphyllobothriasis

Adults are prescribed 2-3 g on an empty stomach, after 2 hours it is necessary to take a saline laxative, the dose is repeated after 1 month.

Children are recommended:

for helminthiasis caused by T. solium, 50 mg per kg of body weight once on an empty stomach, or 2-3 hours after a light breakfast or dinner;

for helminthiasis caused by T. saginata and D. latum, in the same daily doses, but half the dose is taken after breakfast, and the rest after 1 hour, followed by a saline laxative 2 hours after the last dose.

The scientific information provided is general and cannot be used to make a decision about the possibility of using a particular drug.

There are contraindications, consult your doctor.